Current API product portfolio
AcetazolamideSpecification:
|
|
| chemical name: | N-(5-sulphamoyl-1,3,4-thiadiazol-2-yl)acetamide |
| molecular formula: | C4H6N4O3S2 |
| structural formula: |  |
| molecular weight: | 222.2 |
| CAS Registery number: | 59-66-5 |
General information: White to faintly yellowish-white, crystalline, odorless powder. Sparingly soluble in practically boiling water; slightly soluble in alcohol; very slightly soluble in water. |
|
| TESTS | REQUIERMENTS | METHODS |
|---|---|---|
| Identification:
A. IR spectrum B. chemical identification |
corresponds to spectrum obtained with reference substance conforms |
USP |
| Water | not more than 0.5% | USP |
| Residua on ignition | not more than 0.1% | USP |
| Chloride | not more than 0.014% | USP |
| Sulfate | not more than 0.04% | USP |
| Selenium | not more than 0.003% | USP |
| Heavy me |
not more than 0.002% | USP |
| Silver-reducing substances | not less than 4.8 ml of 0.1 N ammoniumthiocyanate | USP |
| Relative substances: - sum of impurities |
not more than 2.0% | USP |
| Residual solvents: - acetic acid - acetone 1) |
loss on drying less than 0.5% |
USP |
| Content of acetazolamide calculated on anhydrous substance | 98.0% - 102.0% | USP |
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